6533b838fe1ef96bd12a47dc
RESEARCH PRODUCT
Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication:A Danish Cohort Study
Aslak Harbo PoulsenKim OvervadKim OvervadUlla Arthur HvidtfeldtNina RoswallAnne TjønnelandJørgen BrandtThomas MünzelSteen Solvang JensenOle Raaschou-nielsenMette SørensenMatthias KetzelMatthias KetzelJesse D. Thachersubject
AdultMalemedicine.medical_specialtyDenmarkHealth Toxicology and MutagenesisENDOTHELIAL FUNCTIONPopulationBLOOD-PRESSUREENVIRONMENTAL NOISEISCHEMIC-HEART-DISEASE010501 environmental sciences01 natural sciencesTRANSPORTATION NOISECohort Studies03 medical and health sciences0302 clinical medicineAir PollutionEnvironmental healthEpidemiologyHumansMedicine030212 general & internal medicineMedical prescriptioneducationAntihypertensive AgentsProportional Hazards Models0105 earth and related environmental sciencesRISKeducation.field_of_studyINCIDENT HYPERTENSIONbusiness.industryProportional hazards modelMORTALITYResearchPublic Health Environmental and Occupational HealthAIR-POLLUTIONEnvironmental ExposureMiddle AgedLONG-TERM EXPOSUREConfidence intervalNoisePrescriptionsNoise TransportationHypertensionCohortFemalebusinessCohort studydescription
BACKGROUND: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS: In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling formula presented prescriptions and formula presented defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models. RESULTS: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals. CONCLUSION: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-05-01 |