6533b838fe1ef96bd12a47f1
RESEARCH PRODUCT
Multiparametric MRI-based Dosimetric Parameters Best Predict Short-term Time Course of PSA After Iodine 125 Permanent Prostate Implantation for Localized Prostate Cancer
Magali QuivrinGilles CréhangeAdèle CueffCéline MirjoletPhilippe MaingonRomaric LoffroyDamien SottierFabienne BidaultEtienne MartinPaul Walkersubject
Entire prostateCancer Researchmedicine.medical_specialtyProstate implantationUrology[INFO.INFO-IM] Computer Science [cs]/Medical Imaging030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicineProstatemedicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingRadiology Nuclear Medicine and imagingRadiation[ INFO.INFO-IM ] Computer Science [cs]/Medical Imagingbusiness.industryMultiparametric MRIPSA bouncemedicine.diseasePeripheral zonemedicine.anatomical_structureOncology030220 oncology & carcinogenesisTime coursebusinessdescription
International audience; D90% and V150% of the entire prostate are recognized as the best dosimetric predictors of outcome after 125 I permanent prostate implantation (PPI). The purpose of this study was 2-fold: 1) to determine the relationship between dose-volume parameters of the Dominant Intraprostatic Lesion (DIL) when compared to the prostate and early biochemical outcome after PPI; 2) to define if dose-volume parameters of the central gland (CG), the peripheral zone (PZ) and the DIL could best predict PSA bounce occurrence. The time course of PSA and mechanisms of bounces still remain unclear after PPI. Patients who had a higher dose in the DIL had a worse PSA level at 1 year which is in keeping with previous reports with a longer follow-up suggesting that patients who will achieve a very low PSA are more likely to require a protracted time after PPI. A strong relationship was found between V150% in the CG and PSA bounce. These pioneering results require further investigations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-10-28 |