6533b838fe1ef96bd12a508c
RESEARCH PRODUCT
Gentamicin, norfloxacin and lysozyme concentration in human tears: in vivo and in vitro study
C. GarcherA. LallemandC. BonninA.m. Bronsubject
AdultMaleAdolescentEgg lysozymechemical and pharmacologic phenomenaIn Vitro TechniquesgentamicinPharmacologyMicrobiologyCorneachemistry.chemical_compoundIn vivomedicineHumansIn vitro studyheterocyclic compounds[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory OrganslysozymeNorfloxacinocular surface[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyChemistryhemic and immune systemsGeneral Medicinebiochemical phenomena metabolism and nutritioninfectionIn vitroOphthalmology[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory OrgansTearsTearsMuramidaseGentamicinGentamicinsOphthalmic SolutionsLysozyme[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyNorfloxacinmedicine.drugdescription
Hen's egg lysozyme (HEL) activity was measured in vitro with gentamicin and norfloxacin by a turbidimetric technique. Gentamicin at the concentration of 10(-3) M inhibited HEL activity by 39%, while 10(-3) M norfloxacin did not affect HEL activity. However, an in vivo study in healthy persons did not show any significant statistical difference in tear lysozyme activity when 0.3% gentamicin or 0.3% norfloxacin were topically applied.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Acta Ophthalmologica |