6533b838fe1ef96bd12a511c

RESEARCH PRODUCT

Use of Micellar Liquid Chromatography to Determine Mebendazole in Dairy Products and Breeding Waste from Bovine Animals

Abhilasha DurgbanshiRajendra-prasad PawarJaume Albiol-chivaJuan Peris-vicenteJosep Esteve-romeroDaniel García-ferrerPooja MishraDevasish Bose

subject

Microbiology (medical)Analytemicellar01 natural sciencesBiochemistryMicrobiologyArticleMatrix (chemical analysis)chemistry.chemical_compoundmedicinePharmacology (medical)AnthelminticGeneral Pharmacology Toxicology and PharmaceuticsSodium dodecyl sulfateDetection limitvalidationmilkChromatographyanthelmintic010405 organic chemistryfood010401 analytical chemistryExtraction (chemistry)lcsh:RM1-950food and beveragesurine0104 chemical sciencesDilutionInfectious Diseaseslcsh:Therapeutics. PharmacologychemistryMicellar liquid chromatographymedicine.drug

description

Mebendazole is an anthelmintic drug used in cattle production. However, residues may occur in produced food and in excretions, jeopardizing population health. A method based on micellar liquid chromatography (MLC) was developed to determine mebendazole in dairy products (milk, cheese, butter, and curd) and nitrogenous waste (urine and dung) from bovine animals. Sample treatment was expedited to simple dilution or solid-to-liquid extraction, followed by filtration and direct injection of the obtained solution. The analyte was resolved from matrix compounds in less than 8 min, using a C18 column and a mobile phase made up of 0.15 M sodium dodecyl sulfate (SDS)&ndash

yearjournalcountryeditionlanguage
2020-02-14Antibiotics
10.3390/antibiotics9020086http://dx.doi.org/10.3390/antibiotics9020086