6533b839fe1ef96bd12a5ca0
RESEARCH PRODUCT
Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections : a prospective multicentre study (WISS Study)
Elif ColakIyiade OlaoyeRaghuveer MnTugan TezcanerDavid W Da CostaVarut LohsiriwatVinod V. PrabhuTadeja PintarFausto CatenaRaul CoimbraDaniel Rios-cruzZaza DemetrashviliDimitrios AnyfantakisIsidoro Di CarloJohn AgboolaKonstantinos PouggourasCharalampos SpyropoulosAa MunyikaSanjay MarwahStefano RauseiGiovanni BellanovaFrancesco PataAndrás VereczkeiPiotr MajorNereo VettorettoAri LeppäniemiRamakrishnapillai PadmakumarGeanina Loredana CurcaOussama BaraketMarco CataniMassimo SartelliMiguel LeonKonstantinos BouliarisMaria Luisa Sánchez De MolinaEftychios LostoridisGianfranco CocorulloBandar AlharthiIonut NegoiZygimantas KuliesiusSanjay GuptaMaurice ZidaTerry CurrySavas BayrakFrederic BrangerPedro LeãoTeresa Giménez MaurelSaleh Abdel KaderCristian MesinaMarcelo A. BeltránEudaldo López-tomassetti FernandezCarlos A. OrdoñezMartin HutanJakub KenigAvidyl KrasniqiSumita A JainTonguç Utku YılmazMiran RemsDmitry SmirnovGabrielle Van RamshorstRobin KaushikRenato Bessa MeloMario Paulo FaroOuadii MouaqitAsri Che JusohAdamu AmhedAbdelkarim H. OmariJaan TeppAli GunerMiklosh BalaCharampolos SeretisAlain Chichom-mefireNadezda DrozdovaMatej SkrovinaSaila KauhanenAurélien VenaraAintzane Lizarazu PérezKuo-ching YuanAdesina AjibadeSilvia Figueiredo CostaYoshimitsu IzawaMahir GachabayovMichael McfarlaneRicardo Alessandro Teixeira GonsagaAshok KshirsagarJae Gil LeeGustavo Pereira FragaKoray DasJan UlrychTamer El ZalabanyLuca AnsaloniVictor Y. KongMatti TolonenJorge PereiraNick MichalopoulosGeorgios GkiokasArda IsikOrestis IoannidisAleix Martínez-pérezSeckin AkkucukGiovanni SinibaldiGabriela Elisa NitaJae Il KimYunfeng CuiFederico CoccoliniEwen A. GriffithsRoberto BiniSalomone Di SaverioMushira EnaniBoris SakakushevMustafa Yener UzunogluAsrhaf AbbasFikri M. Abu-zidanDavid Van DellenSandra GutierrezS DelibegovicIoannis NikolopoulosDaniele BrunelliVishal G ShelatFerdinando AgrestaGerson Alves Pereira JúniorGoran AugustinMantas JokubauskasZeynep ÖZkanSanoop K. ZachariahNutu VladRomeo Lages SimõesKonstantinos LasithiotakisGiorgio VasquezMatthew BoalDaniele MarrelliSanjay Kumar YadavPaola Rodriguez OssaVladimir KhokhaCarlos Augusto GomesJustas ZilinskasGianluca GuercioniRenol M. KoshyGian Luca BaiocchiAthanasios MarinisAleksandar KaramarkovicRadu MoldovanuAndrey V. BorodachMyftar Torbasubject
medicine.medical_specialtyInfections; Intra-abdominal; Sepsis; Septic shock:Ciências da Saúde [Ciências Médicas]Infections; Intra-abdominal; Sepsis; Septic shock; Surgery; Emergency MedicineCiências Médicas::Ciências da SaúdeSepsimedicine.medical_treatment/macromolecular substances030230 surgeryGUIDELINESInfectionsLikelihood ratios in diagnostic testingSepsisPERITONITIS03 medical and health sciencesPROGNOSTIC-FACTORS0302 clinical medicineInternal medicineSepsisSeptic shockMedicine and Health SciencesMANAGEMENTmedicineIntra-abdominalIntra-abdominal SepsisUnivariate analysisScience & TechnologyCOLONIC PERFORATIONReceiver operating characteristicbusiness.industrySeptic shockAbdominal InfectionImmunosuppression3126 Surgery anesthesiology intensive care radiologymedicine.disease3. Good healthSurgery030220 oncology & carcinogenesisInfections Intra-abdominal Sepsis; Septic shockEmergency MedicineSurgeryObservational studyInfectionbusinessSYSTEMResearch Articledescription
BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. ----- METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. ----- RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. ----- CONCLUSIONS: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-12-16 |