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RESEARCH PRODUCT

Predictors of neurocognitive impairment at 3years after a first episode non-affective psychosis

Rocío Pérez-iglesiasRafael Tabarés-seisdedosGema Pardo-garcíaJosé Manuel Rodríguez-sánchezRosa Ayesa-arriolaJosé Luis Vázquez-barqueroJosé Luis Ayuso-mateosBenedicto Crespo-facorro

subject

AdultMalePsychosisAdolescentTrail Making TestPoison controlNeuropsychological TestsYoung AdultMemoryPredictive Value of TestsmedicineHumansLongitudinal StudiesBiological PsychiatryIntelligence TestsPsychiatric Status Rating ScalesPharmacologyFirst episodeTrail Making TestWechsler ScalesNeuropsychologyMiddle AgedPrognosismedicine.diseaseDiagnostic and Statistical Manual of Mental DisordersPsychotic DisordersSocioeconomic FactorsMotor SkillsSchizophreniaSchizophreniaRegression AnalysisFemaleSchizophrenic PsychologyVerbal memoryCognition DisordersPsychologyNeurocognitiveFollow-Up StudiesClinical psychology

description

Abstract Background Neurocognitive impairment is a core component of schizophrenia. However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients. Methods N eurocognitive performance was analyzed in a cohort of 146 patients 3 years after a first episode non-affective psychosis. Subgroups, impaired vs. unimpaired, were compared on baseline clinical, neuropsychological, premorbid and sociodemographic characteristics. Results Fifty-nine percent of participants presented general neurocognitive impairment and regression analyses demonstrated that clinical and sociodemographic characteristics were not predictive variables. A model composed of premorbid IQ, verbal memory and motor dexterity correctly classified 79.6% of the individuals. Conclusions The present study gives information on frequency and neurocognitive profile of subtypes of patients showing impairment. Our results suggest general neurocognitive impairment is a trait dimension of the disorder related to specific cognitive dysfunctions.

yearjournalcountryeditionlanguage
2013-06-01Progress in Neuro-Psychopharmacology and Biological Psychiatry
https://doi.org/10.1016/j.pnpbp.2012.11.012