6533b851fe1ef96bd12a8d75

RESEARCH PRODUCT

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials.

Dariusz HreniakMarta MarkowskaRosa AlduinaMaria Luisa SaladinoAlessandro PresentatoMagdalena WawrzyńskaDariusz BiałyRoberto ScaffaroMariusz HasiakPatrizia CancemiClara Carmone

subject

Materials scienceComposite numberOxide02 engineering and technology010402 general chemistry01 natural scienceslcsh:TechnologyArticlelaw.inventionmedical deviceschemistry.chemical_compoundbiocompatibilitylawGeneral Materials ScienceGraphitelcsh:Microscopygraphene oxide nanocompositeSettore CHIM/02 - Chimica Fisicalcsh:QC120-168.85carboxymethyl celluloseNanocompositelcsh:QH201-278.5Graphenelcsh:T021001 nanoscience & nanotechnologyCastingExfoliation joint0104 chemical sciencesSolventSettore ING-IND/22 - Scienza E Tecnologia Dei MaterialichemistryChemical engineeringlcsh:TA1-2040lcsh:Descriptive and experimental mechanicslcsh:Electrical engineering. Electronics. Nuclear engineering0210 nano-technologylcsh:Engineering (General). Civil engineering (General)lcsh:TK1-9971

description

Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.

yearjournalcountryeditionlanguage
2020-04-23Materials (Basel, Switzerland)
10.3390/ma13081980https://pubmed.ncbi.nlm.nih.gov/32340390