6533b851fe1ef96bd12a9011

RESEARCH PRODUCT

Temporal Trends in Transcatheter Aortic Valve Replacement in France

Vincent AuffretThierry LefevreEric Van BelleHélène EltchaninoffBernard IungRené KoningPascal MotreffPascal LeprinceJean Philippe VerhoyeThibaut ManigoldGeraud SouteyrandDominique BoulmierPatrick JolyFrédéric PinaudDominique HimbertJean Philippe ColletGilles RioufolSaid GhostineOlivier BarAlain DibieDidier ChampagnacLionel LerouxFrédéric ColletEmmanuel TeigerOlivier DarremontThierry FolliguetFlorence LeclercqThibault LhermusierPatrick OlhmannBruno HuretLuc LorgisLaurent DrogoulBernard BertrandChristian SpauldingLaurent QuillietThomas CuissetMaxence DelomezFarzin BeyguiJean-philippe ClaudelAlain HeppArnaud JegouAntoine GommeauxAnfani MirodeLuc ChristiaensCharles ChristopheClaude CassatDamien MetzLionel ManginKarl IsaazLaurent JacqueminPhilippe GuyonChristophe PouillotSerge MakowskiVincent BatailleJosep Rodés-cabauMartine GilardHervé Le BretonHervé Le BretonHélène EltchaninoffMartine GilardBernard IungHerve Le BretonThierry LefevreEric Van BelleMarc LaskarPascal LeprinceBernard IungVincent BatailleBernard ChevalierPhilippe GarotThomas HovasseThierry LefevrePatrick Donzeau GougeArnaud FargeMauro RomanoBertrand CormierErik BouvierJean-jacques BauchartJean-christophe BodartCédric DelhayeDavid HoupeRobert LallemantFabrice LeroyArnaud SudreEric Van BelleFrancis JuthierMohamed KoussaThomas ModineNatacha RousseJean-luc AuffrayMarjorie RichardsonJacques BerlandHélène EltchaninoffMathieu GodinRené KoningJean-paul BessouVincent LetocartThibaut ManigoldJean-christian RousselPhilippe JaafarNicolas CombaretGeraud SouteyrandNicolas D’ostrevyAndréa InnortaGuillaume ClerfondCharles VorilhonVincent AuffretMarc BedossaDominique BoulmierHervé Le BretonGuillaume LeurentAmedeo AnselmiMajid HarmoucheJean-philippe VerhoyeErwan DonalJacques BillePatrick JolyRémi HouelBertrand ViletteWissam Abi KhalilStéphane DelepineOlivier FouquetFrédéric PinaudFrédéric RouleauJérémie AbtanDominique HimbertMarina UrenaSoleiman AlkhoderWalid GhodbaneDimitri ArangalageEric BrochetCoppelia GoublaireOlivier BarthelemyRémi ChoussatJean-philippe ColletGuillaume LebretonPascal LeprinceChiro MastrioanniRichard IsnardRaphael DauphinOlivier DubreuilGuy Durand De GevigneyGérard FinetBrahim HarbaouiSylvain RancGilles RioufolFadi FarhatOlivier JegadenJean-françois ObadiaMatteo PozziSaïd GhostinePhilippe BrenotSahbi FradiAlexandre AzmounPhilippe DeleuzeMartin KloecknerOlivier BarDidier BlanchardChristophe BarbeyStephan ChassaingDidier ChatelOlivier Le PageArnaud TauranDidier BruereLaurent BodsonYvon MeurisseAurélien SeemannNicolas AmabileChristophe CaussinAlain DibieSimon ElhaddadLuc DrieuAlice OhanessianFrançois PhilippeAurélie VeugeoisMatthieu DebauchezKonstantinos ZannisDaniel CzitromChrystelle DiakovFrançois RaouxDidier ChampagnacYves LienhartPatrick StaatOualid ZouaghiVincent DoisyJean Philippe FriehFabrice WautotJulie DementhonOlivier GarrierFadi JamalPierre Yves LerouxFrédéric CasassusLionel LerouxBenjamin SeguyLaurent BarandonLouis LabrousseJulien PeltanClaire CornolleMarina DijosStéphane LafitteGilles BayetClaude CharmassonFrédéric ColletAlain VaillantJacques VicatMarie Paule GiacomoniEmmanuel TeigerEric BergoendCéline ZerbibOlivier DarremontJean Louis LeymariePhilippe ClercEmmanuel ChoukrounNicolas EliaJean-philippe GrimaudJean-philippe GuibaudStéphane WroblewskiEric AbergelEmmanuel BoginoChristophe ChauvelPatrick DehantMarc SimonMichel AngioiJulien LemoineSimon LemoineBatric PopovicThierry FolliguetPablo MaureiraOlivier HuttinChristine Selton SutyGuillaume CaylaDelphine DelsenyFlorence LeclercqGilles LevyJean Christophe MaciaEric MaupasChristophe PiotFrançois RivallandGabriel RobertLaurent SchmutzFrédéric TargoszBernard AlbatArnaud DubarNicolas DurrlemanThomas GandetEmmanuel MunosStéphane CadeFrédéric CransacFrédéric BouissetThibault LhermusierEtienne GrunenwaldBertrand MarcheixPauline FournierOlivier MorelPatrick OhlmannMichel KindoMinh Tam HoangHélène PetitHafida SametAnne TrinhBruno HuretGuillaume LecoqJean François MorellePascal RichardThierry DerieuxEmmanuel MonierCédric JoretLuc LorgisOlivier BouchotJean Christophe EicherLaurent DrogoulPierre MeyerStéphane LopezMichel TapiaJacques TeboulJean-pierre ElbezeAlain MihoubiBernard BertrandGérald VanzettoOlivier WittenbergVincent BachCécile MartinCarole SauierCharlotte CassetPhilippe CastellantMartine GilardEric BezonJean-noel ChoplainAhmed KallifaBahaa NasrYannick JobicDidier BlanchardAntoine LafontJean-yves PagnyChristian SpauldingRamzi Abi AkarJean-noël FabianiRachid ZegdiAlain BerrebiTania PuscasBernard DesveauxFabrice IvanesLaurent QuillietChristophe Saint EtienneThierry BourguignonBlandine AupyRomain PeraultJean-louis BonnetThomas CuissetMarc LambertDominique GrisoliNicolas JaussaudErwan SalaunMaxence DelomezAmine LaghzaouiChristine SavoyeFarzin BeyguiMathieu BignonVincent RouleRémy SabatierCalin IvascauVladimir SaplacanEric SalouxDamien BouchayerJean-philippe ClaudelGuillaume TremeauCamille DiabJoel LapezeFranck PelissierThomas SassardCatherine MatzNicolas MonsarratIvan CarelAlain HeppFranck SibellasAlain CurtilGrégoire DambrinXavier FavereauArnaud JegouGabriel GhorayebLaurent GuesnierWassim KhouryChristophe KucharskiBruno PouzetClaude VaislicRiadh Cheikh-khelifaLoïc HilpertPhilippe MaribasAntoine GommeauxGery HannebicquePhilippe HochartMarc ParisMax PecheuxOlivier FabreLaurent GuesnierLaurent LeborgneAnfani MirodeMarcel PeltierFaouzi TrojetteDoron CarmiChristophe TribouilloyLuc ChristiaensJean MergyPierre CorbiPascale Raud RaynierSylvain CarilloCharles ChristopheArnaud HueberFédéric MoulinGeorges PinelliClaude CassatNicole DarodesFrancis PesteilDamien MetzChadi AludaatFrédéric TorossianLoïc BelleLionel ManginNicolas ChavanisChrystelle AkretAlexis CerisierKarl IsaazJean Pierre FavreJean François FuzellierRomain PierrardLaurent JacqueminOlivier RothJean Yves WiedemannNicolas BischoffGeorghe GavraNicolas BourrelyFranck DignePhilippe GuyonMohammed NajjariVictor StratievNicolas BonnetPatrick MesnildreyDavid AttiasJulien DreyfusDaniel Karila CohenThierry LapercheJulien NahumAliocha ScheubleChristophe PouillotGeoffrey RambaudEric BraubergerMichel Ah HotPhilippe AllouchFabrice BeverelliSerge MakowskiJulien RosencherStéphane AubertJean Michel GrindaThierry Waldman

subject

Aortic valvemedicine.medical_specialtymedicine.medical_treatmentnational registry030204 cardiovascular system & hematologyoutcomes03 medical and health sciences0302 clinical medicineValve replacementCardiac tamponadeMedicine030212 general & internal medicineComputingMilieux_MISCELLANEOUSAortic dissectionbusiness.industryMortality ratetransfemoralEuroSCORE[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemmedicine.diseasepacemaker3. Good healthSurgeryStenosisCathetermedicine.anatomical_structureCardiology and Cardiovascular Medicinebusiness

description

Background - Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. Objectives - The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. Methods - TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry. Findings were further compared with those reported from the FRANCE 2 (French Aortic National CoreValve and Edwards 2) registry, which captured all TAVRs performed from January 2010 to January 2012 across 34 centers. Results - A total of 12,804 patients from FRANCE TAVI and 4,165 patients from FRANCE 2 were included in this analysis. The median age of patients was 84.6 years, and 49.7% were men. FRANCE TAVI participants were older but at lower surgical risk (median logistic European System for Cardiac Operative Risk Evaluation [EuroSCORE]: 15.0% vs. 18.4%; p < 0.001). More than 80% of patients in FRANCE TAVI underwent transfemoral TAVR. Transesophageal echocardiography guidance decreased from 60.7% to 32.3% of cases, whereas more recent procedures were increasingly performed in hybrid operating rooms (15.8% vs. 35.7%). Rates of Valve Academic Research Consortium-defined device success increased from 95.3% in FRANCE 2 to 96.8% in FRANCE TAVI (p < 0.001). In-hospital and 30-day mortality rates were 4.4% and 5.4%, respectively, in FRANCE TAVI compared with 8.2% and 10.1%, respectively, in FRANCE 2 (p < 0.001 for both). Stroke and potentially life-threatening complications, such as annulus rupture or aortic dissection, remained stable over time, whereas rates of cardiac tamponade and pacemaker implantation significantly increased. Conclusions - The FRANCE TAVI registry provided reassuring data regarding trends in TAVR performance in an all-comers population on a national scale. Nonetheless, given that TAVR indications are likely to expand to patients at lower surgical risk, concerns remain regarding potentially life-threatening complications and pacemaker implantation. (Registry of Aortic Valve Bioprostheses Established by Catheter [FRANCE TAVI]; NCT01777828).

yearjournalcountryeditionlanguage
2017-07-01
https://hal.archives-ouvertes.fr/hal-01654889