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RESEARCH PRODUCT
Electrochemical detection and screening of bladder cancer recurrence using direct electrochemical analysis of urine: A non-invasive tool for diagnosis
Sara VillaroyaDavid RamosJosefina ArtesClara Doménech-casasúsJosé Luís PontonesAntonio Doménech-carbósubject
medicine.medical_specialtyUrinary systemUrology02 engineering and technologyElectrochemical detectionUrineUrine010402 general chemistry01 natural sciencesUrothelial cell carcinomaMaterials ChemistrymedicineElectrochemistryElectrical and Electronic EngineeringInstrumentationBladder cancermedicine.diagnostic_testbusiness.industryNon invasiveBladder cancerMetals and AlloysCystoscopyNon-invasive diagnostic021001 nanoscience & nanotechnologyCondensed Matter Physicsmedicine.disease0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsClinical trial0210 nano-technologybusinessdescription
Although detection of urothelial cell carcinoma (or bladder cancer, BC) can be performed via cytological, molecular and genetic marker tests on urine, cystoscopy, an invasive technique, still remains as the gold methodology in clinical practice. It is presented a non-invasive method for detecting BC recurrence consisting of a direct electrochemical test in urine combining voltammetric data at gold and glassy carbon electrodes. The diagnosis is based on the ratio between characteristic voltammetric features recorded for tryptophan, serotonin and melatonin and other related metabolites. The method was tested by means of a clinical trial with 30 patients diagnosed of bladder cancer and a two control groups: 17 healthy volunteers and 15 patients diagnosed of other urinary pathologies and permitted detection of non-muscle invasive stages (pTa, pT1) and muscle-invasive stages (pT2 cancers) of BC. (C) 2018 Elsevier B.V. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-01 |