6533b851fe1ef96bd12a974c

RESEARCH PRODUCT

ChemInform Abstract: Investigations Concerning the COX/5-LOX Inhibiting and Hydroxyl Radical Scavenging Potencies of Novel 4,5-Diaryl Isoselenazoles.

Gerd DannhardtHolger UlbrichMichael Scholz

subject

chemistry.chemical_classificationReactive oxygen speciesRadicalInflammationGeneral MedicinePharmacologyMultiple targetmedicine.diseasechemistry.chemical_compoundchemistryRheumatoid arthritismedicineHydroxyl radicalmedicine.symptom

description

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds. Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson's disease, Alzheimer's disease and rheumatoid arthritis.

yearjournalcountryeditionlanguage
2008-10-14ChemInform
https://doi.org/10.1002/chin.200842177