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RESEARCH PRODUCT
FOXP2 polymorphisms in patients with schizophrenia.
María Dolores MoltóC. NájeraAmparo TolosaEduardo J. AguilarRosa De FrutosJ.c. GonzálezJulio Sanjuánsubject
OncologyAdultMalemedicine.medical_specialtyPsychosisGenotypeHallucinationsSeverity of Illness IndexExonPolymorphism (computer science)Internal medicinemedicineSNPHumansGenetic Predisposition to DiseaseAlleleBiological PsychiatryAllelesAgedDNA PrimersRetrospective StudiesGeneticsLanguage DisordersFOXP2 GenePolymorphism GeneticTransition (genetics)business.industryForkhead Transcription FactorsExonsMiddle Agedmedicine.diseaseIntronsDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthSchizophreniaSchizophreniaFemalebusinessTranscription Factorsdescription
Abstract Background FOXP2 was described as the first gene involved in our ability to acquire spoken language. The main objective of this study was to compare the distribution of FOXP2 gene polymorphisms between patients with schizophrenia and healthy controls. Methods Two FOXP2 polymorphisms, Intron3a and SNP 923875, and the G→A transition in exon 14 were analysed in 149 patients with schizophrenia and schizoaffective disorders according to DSM-IV, as well as in 137 controls. All the patients showed a history of auditory hallucinations. Results The transition G→A at exon 14, detected in all the affected members in KE family, was not found in any of the analyzed samples from patients or controls. No significant differences were found between individual controls and patients for the two analysed polymorphisms. Conclusions This study would not support a possible role of the two FOXP2 analyzed polymorphisms in the vulnerability to schizophrenia.
year | journal | country | edition | language |
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2005-03-01 | Schizophrenia research |