Zur Aktivit�t der 17 ?-hydroxysteroid-oxidoreduktase in erythrocyten von psoriatikern

6533b853fe1ef96bd12aca78

RESEARCH PRODUCT

Zur Aktivit�t der 17 ?-hydroxysteroid-oxidoreduktase in erythrocyten von psoriatikern

H. Holzmann Hoffmann G B. Morsches G. Hoffmann-trefz G. W. Oertel

subject

Chemistry Dermatology General Medicine Molecular biology

description

Hamolysate von 7 Psoriatikern und 7 Kontrollpersonen wurden mit 7α-3H-DHEA in Gegenwart eines Uberschusses an NADPH inkubiert. Die anschliesende Bestimmung Tritium-markierter C19-Steroide ergab bei den Psoriatikern im Vergleich zu den Kontrollpersonen eine signifikante Erhohung der ADIOL-Bildung und eine signifikant verminderte Konzentration der 17-Oxosteroide DHEA, ADION, ANDRO und ATIO. Die Ergebnisse weisen auf eine NADPH-unabhangige Steigerung der 17β-Hydroxysteroid-oxidoreduktase in Erythrocyten von Psoriatikern hin, die auf einer quantitativen und/oder qualitativen Veranderung des Enzymproteins beruht.

year	journal	country	edition	language
1974-01-01	Archives for Dermatological Research

https://doi.org/10.1007/bf00561194

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