6533b855fe1ef96bd12b07e3
RESEARCH PRODUCT
Portraying infective endocarditis
Ilker Inanc BalkanNajada ComoAndré Silva-pintoAntonio CascioCanan AgalarMeliha Meric-kocTatjana Lejko ZupancOday Abu AjamiehSimin Aysel FlorescuSelma TosunMeltem TaşbakanAsuman InanRosa Fontana Del VecchioEdmond PucaGüven ÇElebiAyse Sagmak-tartarAbdullah Umut PekokYasemin CagGülden ErsözSumeyra KarakusSafak Ozer-balinJamal WadiSukran KoseYves HansmannHacer Deniz OzkayaNefise OztoprakHakan ErdemSerkan OncuJesper Damsgaard GunstYvon RuchAyşegül ErdemGilda TonzielloAyse BatirelRahmet GunerIrina Magdalena DumitruLurdes SantosRaquel DuroNesrin Ghanem-zoubiArjeta DedejSerda GulsunMustafa DoganNecla TulekAlper ŞEnerPedro Palma MartinsIlkay BozkurtDeborah KonopnickiFatma SirmatelXavier ArgemiMeltem AvciFahad AlmajidRecep TekinNicola PetrosilloCorneliu Petru PopescuAyse Kaya-kalemImran HasanogluAtilla IyisoyJean Philippe MazzucotelliEjaz Ahmed KhanSema SarıDerya Ozturk-enginNicolas Daubysubject
MaleInternationalityAucunInfective endocarditimedicine.disease_causeMedical microbiology80 and overBlood cultureHospital MortalityAged 80 and overmedicine.diagnostic_testbiologyEndocarditisSBacterialGeneral MedicineSciences bio-médicales et agricolesMiddle AgedStaphylococcal InfectionsSciences du Vivant [q-bio]/Microbiologie et ParasitologieViridans StreptococciCatheterInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyStaphylococcus aureusInfective endocarditisAortic ValveMitral ValveFemaleMicrobiology (medical)Adultmedicine.medical_specialtyProsthesis-Related InfectionsAdolescentaureusBlood cultureYoung AdultInternal medicinemedicineEndocarditisHumansresults of multinational ID-IRI study- EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES cilt.38 ss.1753-1763 2019 [Erdem H. Puca E. Ruch Y. Santos L. Ghanem-Zoubi N. Argemi X. Hansmann Y. Guner R. Tonziello G. Mazzucotelli J. et al. -Portraying infective endocarditis]ProstheticAgedNative Valve EndocarditisBacteriabusiness.industryEndocarditis Bacterialmedicine.diseasebiology.organism_classificationS. aureusViridans streptococciInfective endocarditisbusinessNativedescription
Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-01 |