6533b855fe1ef96bd12b089d
RESEARCH PRODUCT
Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection
Laura Pérez-lagoHelena Martínez LozanoJosé Antonio Pajares DíazArantxa Díaz GómezMarina MachadoPedro J. Sola-campoyMarta HerranzSergio Buenestado-serranoMaricela ValerioMaría OlmedoCristina Andrés ZayasIñaki ComasFernando González-candelasRafael BañaresPilar CatalánPatricia MuñozDarío García De ViedmaGregorio Marañón Microbiology-id Covid 19 Study Groupsubject
0301 basic medicineMalePediatricsmedicine.medical_specialty2019-20 coronavirus outbreakFatal outcomeCoronavirus disease 2019 (COVID-19)Hospitalized patientsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Antibodies Viral03 medical and health sciences0302 clinical medicineNosocomial transmissionRecurrencemedicineImmunology and AllergyHumans030212 general & internal medicineAgedFirst episodeWhole Genome Sequencingbusiness.industrySARS-CoV-2Nosocomial transmissionBrief ReportCOVID-19Reactivation030104 developmental biologyInfectious DiseasesAcademicSubjects/MED00290ReinfectionbusinessWGSdescription
A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. However, whole-genome-sequencing indicated that case R recurrence corresponded to a reactivation of the strain involved in his first episode. Case R reactivation had major consequences, leading to a more severe episode, and causing a subsequent transmission to another two hospitalized patients, one of them with fatal outcome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-06-09 |