Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease

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RESEARCH PRODUCT

Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease

Giulia Ruina Beatrice Raone Claudia De Cupis Paolo Amerio Paolo Broganelli Valentina Dini Luisa Di Costanzo Michele Lo Re Giulia Giovanardi Leonardo Pescitelli Federica Sanna Nevena Skroza Laura Atzori Giulia Merlo Raffaele Dante Caposiena Caro Chiara Franchi Claudia Lasagni Giuseppe Argenziano Serafinella P. Cannavò Marina Venturini Marco Ardigò Stefano Veraldi Maria Rita Bongiorno Alberto Maria Bertoldi Luca Stingeni Federica Fiorentini Valeria Saragaglia Elisa Molinelli Giuliana Gualberti Gabriella Fabbrocini

subject

Burden of disease Adult Male medicine.medical_specialty HIDRAdisk Dermatology Disease Severity of Illness Index Burden of disease; HIDRAdisk; Hidradenitis suppurativa; Quality of life Cohort Studies Young Adult Quality of life Cost of Illness Internal medicine medicine Humans Hidradenitis suppurativa Prospective Studies Stage (cooking)Disease burden Quality of life.Prostaglandins A business.industry Burden of disease Dermatology Life Quality Index Middle Aged medicine.disease Cost of Illne Prospective Studie Hidradenitis suppurativa Italy Quality of Life Female Cohort Studie business Cohort study Human

description

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually occurs after puberty with painful, deep-seated, inflamed nodules and sinus tracts in the apocrine gland-bearing areas of the body, most commonly the axillae and inguinal and anogenital regions, with a relevant impact on patients’ quality of life (QoL). Objective: To evaluate how the burden of HS disease impacts on patient well-being and working activities in a large Italian population over a period of 9 months. Methods: A multicenter, prospective, epidemiologic cohort study was conducted in adult Italian patients with HS. HS severity was assessed through Hurley stage and HS Physician’s Global Assessment (HS-PGA), clinical improvement by HS Clinical Response (HiSCR) and partial response, and disease burden through QoL questionnaires (HIDRAdisk, Skindex-16, Dermatology Life Quality Index [DLQI]), and Work Productivity and Activity Impairment – General Health (WPAI:GH). Results: A total of 308 patients (56.2% women; mean age 35.2 ± 12.9 years) were enrolled in 27 dermatologic clinics. Men were older (37.4 years vs. 33.5), more smoking addicted (74.1% vs. 60.1%), and alcohol consumer (34.1% vs. 13.9%), while more women were obese (34.10% vs. 22.22%). At baseline, most patients had a Hurley severity stage of 2 (43.9%), a moderate HS-PGA score (57.1%), and poor QoL (HIDRAdisk: 65.7 ± 23.3, Skindex-16: 60.3 ± 26.9, and DLQI: 10.8 ± 8.1). Patients with more severe disease showed worse QoL. Mean values for the variables related to HS severity decreased during the study period. The achievement of HiSCR and partial response increased during the study. Conclusion: This study offers insight into the disease burden of HS in an Italian population. Our results underline the impact of QoL evaluation, also with the use of the HIDRAdisk, in clinical routine as a support to validated severity clinical and instrumental indexes for a “360-degree” assessment of HS patient’s burden of disease.

year	journal	country	edition	language
2022-01-01

10.1159/000517412 https://hdl.handle.net/10447/582526