6533b856fe1ef96bd12b1e0e
RESEARCH PRODUCT
A study of beta-adrenoceptors in rat lung parenchymal strip.
Maria L. CandenasElsa Anselmisubject
AgonistMalemedicine.medical_specialtymedicine.drug_classPopulationPharmaceutical SciencePropranololPharmacologyIn Vitro TechniquesButoxamineNorepinephrineInternal medicineIsoprenalineReceptors Adrenergic betamedicineAnimalsAlbuterolBeta (finance)educationLungPharmacologyeducation.field_of_studyChemistryAntagonistIsoproterenolAtenololPropranololButoxamineRatsEndocrinologyAtenololmedicine.drugdescription
Abstract The aim of the present study was to characterize the β-adrenoceptor population in rat lung strip. For this purpose, Schild plots were obtained for the β-adrenoceptor antagonists atenolol (β1-selective), butoxamine (β2-selective) and propranolol (nonselective), using three different agonists: isoprenaline (non-selective), salbutamol (β2-selective) and noradrenaline (β11-selective). The slopes of these Schild plots were close to the theoretical value of unity, and pA2 values determined with isoprenaline, salbutamol and noradrenaline as agonists were: for propranolol, 7·86 ± 0·22, 7·72 ± 0·15 and 7·89 ± 0·23; for atenolol, 5·19 ± 0·05, 5·33 ± 0·07 and 5·47 ± 0·22 and for butoxamine, 6·31 ± 0·11, 6·34 ± 0·03 and 5·99 ± 0·23, respectively. These data suggest that pharmacological responses of rat isolated lung strip to β-adrenoceptor agents are mediated by a homogeneous population of β2-adrenoceptors, although the presence of a minor population of β1-adrenoceptors undetected by the agonists used cannot be excluded.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-05-01 | The Journal of pharmacy and pharmacology |