6533b856fe1ef96bd12b25ad
RESEARCH PRODUCT
Zur Wirkung von Butazolidin im Intermedi�rstoffwechsel
K. H. BässlerKonrad Langsubject
Pharmacologychemistry.chemical_classificationOxidase testRespiratory chainGeneral MedicineCitric acid cyclechemistry.chemical_compoundEnzymechemistryBiochemistryAcetate thiokinaseXanthine oxidaseOxidative decarboxylationPyruvate decarboxylasedescription
Butazolidin (Phenylbutazone) inhibits the oxidative decarboxylation of pyruvate and α-ketoglutarate in a final concentration of 10 mg-% (3,24 · 10−4 m). Data are presented suggesting that the β-ketothiolase is inhibited. The following enzymes or enzyme systems are not inhibited: The enzymes of the respiratory chain, the enzymes of the citric acid cycle with exception of α-ketoglutaric oxidase, the glycolysis of hexosediphosphate (slight inhibition), acetate thiokinase, sulfanilamid transacetylase, pyruvic decarboxylase from yeast, arginase, xanthine oxidase, and D-amino acid oxidase.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1956-01-01 | Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie |