6533b856fe1ef96bd12b27fb
RESEARCH PRODUCT
Silicon Nanowire Sensors Enable Diagnosis of Patients via Exhaled Breath
Gerald BrönstrupOri LiranNir PeledNisreen ShehadaMichael P.a. DaviesEnrique S. ParienteJohn C. CancillaJosé S. TorrecillaMarcis LejaDouglas W. JohnsonHossam HaickSilke ChristiansenSilke Christiansensubject
Lung DiseasesSiliconVolatile Organic CompoundsMaterials scienceTraining setNanowiresGeneral EngineeringGeneral Physics and AstronomyPulmonary diseaseNanotechnology02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesAsthma3. Good health0104 chemical sciencesBreath TestsOthersHumansGeneral Materials Science0210 nano-technologySilicon nanowiresBiomedical engineeringdescription
Two of the biggest challenges in medicine today are the need to detect diseases in a noninvasive manner and to differentiate between patients using a single diagnostic tool. The current study targets these two challenges by developing a molecularly modified silicon nanowire field effect transistor (SiNW FET) and showing its use in the detection and classification of many disease breathprints (lung cancer, gastric cancer, asthma, and chronic obstructive pulmonary disease). The fabricated SiNW FETs are characterized and optimized based on a training set that correlate their sensitivity and selectivity toward volatile organic compounds (VOCs) linked with the various disease breathprints. The best sensors obtained in the training set are then examined under real-world clinical conditions, using breath samples from 374 subjects. Analysis of the clinical samples show that the optimized SiNW FETs can detect and discriminate between almost all binary comparisons of the diseases under examination with80% accuracy. Overall, this approach has the potential to support detection of many diseases in a direct harmless way, which can reassure patients and prevent numerous unpleasant investigations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-14 |