6533b856fe1ef96bd12b3101

RESEARCH PRODUCT

The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome

Francesco Paolo BusardòGuido RomanoNunziata BarberaFrancesca Indorato

subject

MalePyrrolidinesDrug ContaminationLidocainePharmacologyKidneyDextromethorphanDrug Userschemistry.chemical_compoundBileAnesthetics LocalForensic PathologyLungAdulterantMorphineDextromethorphanGastrointestinal ContentsLiverFemaleDrug ContaminationCaffeineSelective Serotonin Reuptake Inhibitorsmedicine.drugAdultNarcoticsSubstance-Related DisordersCitalopramDrug overdosePathology and Forensic MedicineForensic ToxicologyRoute of administrationAdulterantsCaffeinemedicineHumansBrain ChemistryMorphine DerivativesCodeineIllicit Drugsbusiness.industryForensic toxicologyAdulterants Lidocaine Caffeine DextromethorphanLidocainemedicine.diseaseVitreous BodyAntitussive AgentschemistryCentral Nervous System StimulantsDrug OverdosebusinessLawMethadone

description

The purpose of the present study is to determine the role of lidocaine, caffeine and dextromethorphan, used as adulterant substances, in five cases of drug overdose which have come to our attention. Taking into account the pharmacological mechanism, blood concentration and route of administration (intravenous) we evaluated the hypothesis that these substances could act with a synergistic effect - or at least additive - with the illicit drugs on the central nervous system and cardiovascular system.

yearjournalcountryeditionlanguage
2013-04-01Forensic Science International
https://doi.org/10.1016/j.forsciint.2012.08.041