6533b857fe1ef96bd12b4f58

RESEARCH PRODUCT

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

Helena PinheiroAntonio L. SerranoWilliam RomanWilliam RomanMa Carmen Gómez-cabreraJessica SegalésLuis M. OliveiraEdgar R. GomesPura Muñoz-cánovesPura Muñoz-cánovesMafalda R. PimentelEsther Garcia-dominguez

subject

Calcium metabolismMultidisciplinaryChemistryRegeneration (biology)Skeletal muscleCell biologymedicine.anatomical_structuremedicineStem cellmedicine.symptomNuclear migrationSignal transductionProcess (anatomy)Muscle contraction

description

Muscle repair without stem cells Skeletal muscle is a mechanical organ that endures cellular damage after contraction. Lesions caused by external injury can be repaired by muscle stem cells, which fuse with injured cells or create entirely new myofibers. Roman et al . describe a cell-autonomous repair process that is independent of muscle stem cells (see the Perspective by McNally and Demonbreun). After localized damage, myonuclei migrate to injury sites and locally deliver messenger RNA for cellular reconstruction. This myofiber self-repair represents a model for understanding the restoration of muscle architecture in health and disease. —BAP

yearjournalcountryeditionlanguage
2021-10-15science
10.1126/science.abe5620http://dx.doi.org/10.1126/science.abe5620