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RESEARCH PRODUCT
Dynamical properties of water in living cells
Claire RomeClaire RomeIrina PiazzaNora CollombNora CollombEmmanuel L. BarbierEmmanuel L. BarbierAntonio CupaneFrancesca NataliMiguel A. GonzalezJacques Olliviersubject
Properties of waterScale (ratio)HydrogenPhysics and Astronomy (miscellaneous)chemistry.chemical_elementNeutron scattering010402 general chemistrySpace (mathematics)01 natural sciencesSignalchemistry.chemical_compoundOpticsquasi-elastic neutron scatteringwater structure and dynamicintracellular water0103 physical sciences010306 general physicsintracellular water; quasi-elastic neutron scattering; water structure and dynamics; Physics and Astronomy (miscellaneous)Physicsbusiness.industryScatteringSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)0104 chemical scienceswater structure and dynamicschemistryPicosecondbusinessBiological systemdescription
With the aim of studying the effect of water dynamics on the properties of biological systems, in this paper, we present a quasi-elastic neutron scattering study on three different types of living cells, differing both in their morphological and tumor properties. The measured scattering signal, which essentially originates from hydrogen atoms present in the investigated systems, has been analyzed using a global fitting strategy using an optimized theoretical model that considers various classes of hydrogen atoms and allows disentangling diffusive and rotational motions. The approach has been carefully validated by checking the reliability of the calculation of parameters and their 99% confidence intervals. We demonstrate that quasi-elastic neutron scattering is a suitable experimental technique to characterize the dynamics of intracellular water in the angstrom/picosecond space/time scale and to investigate the effect of water dynamics on cellular biodiversity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |