6533b85afe1ef96bd12b8c1e
RESEARCH PRODUCT
Failure of opioids to affect excitation and contraction in isolated ventricular heart muscle
F. MertzlufftU. SackHelga JakobJohanna RuppW. DickHermann Nawrathsubject
medicine.medical_specialtyContraction (grammar)EthylketocyclazocineGuinea PigsAction PotentialsEthylketocyclazocineBiologyGuinea pigNorepinephrineCellular and Molecular NeuroscienceInternal medicineHeart ratemedicineAnimalsCyclazocineHumansOpioid peptideMolecular BiologyPharmacologyMorphineNaloxoneCell BiologyPapillary MusclesMyocardial ContractionAcetylcholineEndocrinologyOpioidSynapsesCirculatory systemMolecular MedicineRabbitsAcetylcholinemedicine.drugdescription
The opioid agonists morphine (selective for mu-receptors) and ethylketocyclazocine (selective for kappa-receptors), at concentrations evoking strong effects in neuronal structures, did not significantly affect the configuration of the intracellularly recorded action potential and the force of contraction in ventricular heart muscle isolated from guinea pigs, rabbits and man. These results suggest that any changes of heart functions in vivo in response to opioid-like drugs are probably not mediated postsynaptically at the myocardial cell membrane but rather presynaptically, influencing the release of noradrenaline and/or acetylcholine from the nerve terminals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-04-01 | Experientia |