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RESEARCH PRODUCT
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
Johannes SchumacherDaniel BrandeisFerenc HonbolygóDarina CzamaraDénes TóthStéphanie IannuzziJuha KereJuha KereAnniek VaessenSilvia ParacchiniSilvia ParacchiniValéria CsépeMarkus M. NöthenJohn F. SteinMyriam Peyrard-janvidIsabelle Soares-boucaudKerstin U. LudwigSylviane ValdoisPaavo H.t. LeppänenJessica BeckerLohvansuu KaisaUrs MaurerChristophe Loïc GérardThomas S. ScerriThomas S. ScerriCaroline BogliottiBertram Müller-myhsokSanne Van Der MarkEnrico SchulzPer HoffmannPer HoffmannFabien FauchereauFabien FauchereauMarco ZucchelliHeikki LyytinenJennifer BruderKarin LanderlFranck RamusLeo BlomertAndrew P. MorrisFlorence GeorgeCatherine BillardJoel B. TalcottGerd Schulte-körneYves ChaixAnthony P. Monacosubject
Candidate geneDyslexia10064 Neuroscience Center Zurich10. No inequalityGenetics (clinical)ta515Geneticseducation.field_of_study10093 Institute of PsychologyR10058 Department of Child and Adolescent Psychiatry3. Good healthAssociation studyPhenotype10076 Center for Integrative Human PhysiologyWord-reading[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Reading disability2716 Genetics (clinical)GenotypePopulationLocus (genetics)610 Medicine & healthSpellingQH426 GeneticsBDYBiologyR Medicineta3111Polymorphism Single NucleotideArticleCandidate genesQuantitative Trait HeritableMeta-Analysis as Topic1311 GeneticsDCDC2mental disordersGeneticsmedicineHumanseducationQH426Genetic Association StudiesGenetic associationHaplotypeDyslexiamedicine.diseaseHaplotypesGenetic LociCase-Control Studies570 Life sciences; biology150 PsychologyGenome-Wide Association Studydescription
The work conducted at the WTCHG was supported by Wellcome Trust grants [076566/Z/05/Z] and [075491/Z/04]; the work in Zurich partly by an SNSF grant [32-108130]. We also thank MAF (Mutation Analysis core Facility) at the Karolinska Institute, Novum, Huddinge. The French part of the project was funded by Agence Nationale de la Recherche (ANR-06-NEURO-019-01 GENEDYS) and Ville de Paris. S Paracchini is a Royal Society University Research Fellow. D Czamara was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy). Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects. Postprint Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-11 |