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RESEARCH PRODUCT

Multivalency Beats Complexity: A Study on the Cell Uptake of Carbohydrate Functionalized Nanocarriers to Dendritic Cells.

Robert ForsterDanuta KowalczykMarie-luise FreyMatthias KrumbTill OpatzJens LanghankiVolker MailänderKatharina Landfester

subject

CellcarbohydratesBlood DonorsHydroxyethyl starch010402 general chemistryLigands01 natural sciencesNanocapsulesArticleHydroxyethyl Starch DerivativesDrug Delivery SystemsDendrimermedicineHumanslcsh:QH301-705.5Cells Cultured010405 organic chemistryChemistrynanocapsulesBiological TransportGeneral MedicineDendritic cellDendritic CellsCarbohydrate0104 chemical sciencesMiniemulsionmedicine.anatomical_structurelcsh:Biology (General)BiophysicsglycodendronsNanocarrierscell targetingmedicine.drug

description

Herein, we report the synthesis of carbohydrate and glycodendron structures for dendritic cell targeting, which were subsequently bound to hydroxyethyl starch (HES) nanocapsules prepared by the inverse miniemulsion technique. The uptake of the carbohydrate-functionalized HES nanocapsules into immature human dendritic cells (hDCs) revealed a strong dependence on the used carbohydrate. A multivalent mannose-terminated dendron was found to be far superior in uptake compared to the structurally more complex oligosaccharides used.

yearjournalcountryeditionlanguage
2020-09-12Cells
10.3390/cells9092087https://pubmed.ncbi.nlm.nih.gov/32932639