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RESEARCH PRODUCT
Synthesis, characterization, and thermal behavior of steroidal dendrons
Kari RissanenJuha LinnantoJarmo RopponenJari TamminenErkki KolehmainenManu Lahtinensubject
Aliphatic estersThermogravimetric analysisDendrimersLithocholic acidHydrogen bondOrganic ChemistryDeoxycholic acidCholic acidBile acidschemistry.chemical_compoundchemistryDendrimerPolymer chemistryOrganic chemistryMoleculeHydroxymethylSteroidsThermal analysisPhysical and Theoretical Chemistrydescription
A series of novel dendritic steroidal polyesters of first and second generation has been synthesized in convergent fashion by the use of 2,2-bis(hydroxymethyl)propionic acid as a repeating unit. The first- and second-generation hydroxy-functionalized dendrons with a variety of surface modifications were produced through the use of four bile acids: lithocholic acid (LCA), ursodeoxycholic acid (UDCA), deoxycholic acid (DCA), and cholic acid (CA). The thermal behavior of the steroidal dendrons was characterized by differential scanning calorimetry (DSC) and by thermogravimetric analysis (TGA). Finally, quantum chemical calculation methods were used to study the geometries of the dendrons and the occurrence of intramolecular hydrogen bonds in these dendritic molecules. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-12-27 | European Journal of Organic Chemistry |