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RESEARCH PRODUCT
The Inflammatory Role of Platelets : Translational Insights from Experimental Studies of Autoimmune Disorders
Susann PankratzSven G. MeuthKerstin GöbelBeate E. KehrelStefan BittnerChristoph KleinschnitzHarald F. Langersubject
Blood Platelets0301 basic medicineMultiple SclerosisMedizinInflammationReviewmedicine.disease_causeCatalysisAutoimmune DiseasesneuroinflammationAutoimmunityArthritis Rheumatoidlcsh:ChemistryInorganic Chemistry03 medical and health sciences0302 clinical medicineImmune systemAnimalsHumansMedicinePlateletPhysical and Theoretical ChemistryReceptorlcsh:QH301-705.5Molecular BiologySpectroscopyNeuroinflammationInflammationbusiness.industryMultiple sclerosisautoimmunityOrganic ChemistryGeneral MedicineInflammatory Bowel Diseasesmedicine.diseaseComputer Science Applications030104 developmental biologylcsh:Biology (General)lcsh:QD1-999030220 oncology & carcinogenesisplateletsImmunologymedicine.symptomSignal transductionbusinessdescription
Beyond their indispensable role in hemostasis, platelets have shown to affect the development of inflammatory disorders, as they have been epidemiologically and mechanistically linked to diseases featuring an inflammatory reaction in inflammatory diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disorders. The identification of novel molecular mechanisms linking inflammation and to platelets has highlighted them as new targets for therapeutic interventions. In particular, genetic and pharmacological studies have identified an important role for platelets in neuroinflammation. This review summarizes the main molecular links between platelets and inflammation, focusing on immune regulatory factors, receptors, cellular targets and signaling pathways by which they can amplify inflammatory reactions and that make them potential therapeutic targets. OA gold - CA extern
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-01 |