6533b85dfe1ef96bd12be92d
RESEARCH PRODUCT
Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum
Armando GrassiaFelice SenatoreDaniela RiganoGabriella AvielloRaffaele CapassoFranco PiozziFrancesca BorrelliMaurizio BrunoNelly Apostolides Arnoldsubject
MaleBlotting WesternPharmaceutical ScienceNitric Oxide Synthase Type IIPharmacognosyLABDANE DITERPENOIDSCarrageenanDinoprostoneAnalytical Chemistrylaw.inventionLabdanechemistry.chemical_compoundMicelawDrug DiscoveryBotanyVULGAREAnimalsEdemaRats WistarPharmacologybiologyTraditional medicinePlant ExtractsOrganic ChemistryAnti-Inflammatory Agents Non-SteroidalCYLLENEUMPlant Components Aerialbiology.organism_classificationCarrageenanRatsComplementary and alternative medicinechemistryPhytochemicalMacrophages PeritonealMolecular MedicineLamiaceaeVELUTINUMDiterpenePhytotherapyMarrubiumMarrubiumPhytotherapydescription
A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 |