Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

6533b85efe1ef96bd12bfdf4

RESEARCH PRODUCT

Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

David Dahlgren Hans Lennernäs Alkwin Wanders Per M. Hellström Maria-jose Cano-cebrián Markus Sjöblom

subject

Male medicine.medical_treatment single-pass intestinal perfusion Pharmacology lcsh:Chemistry chemistry.chemical_compound Pharmaceutical Sciences Pharmaceutical sciences Sodium dodecyl sulfate Intestinal Mucosa Misoprostol lcsh:QH301-705.5 Spectroscopy media_common Melatonin Sodium Dodecyl Sulfate General Medicine Absorció intestinal Computer Science Applications Intestines Perfusion Drug Combinations Single-pass intestinal perfusion Phenobarbital gastrointestinal physiology Misoprostol medicine.drug Drug Farmacologia media_common.quotation_subject Gastroenterology and Hepatology Intestinal permeability Catalysis Permeability Article Inorganic Chemistry Melatonin medicine Gastroenterologi Animals Physical and Theoretical Chemistry Rats Wistar Molecular Biology Edetic Acid Chemotherapy Intestinal permeability Gastrointestinal Physiology business.industry intestinal permeability Organic Chemistry medicine.disease Farmaceutiska vetenskaper Rats Intestinal Diseases chemistry lcsh:Biology (General)lcsh:QD1-999 Intestinal barrier dysfunction Gastrointestinal physiology business intestinal barrier dysfunction

description

A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs&mdash

year	journal	country	edition	language
2020-09-15	International Journal of Molecular Sciences

10.3390/ijms21186771 https://www.mdpi.com/1422-0067/21/18/6771

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