6533b85ffe1ef96bd12c1066
RESEARCH PRODUCT
Characterisation of beam focus quality in biomedical nuclear microscopy: A Fourier optics approach
Thomas OsipowiczFrank WattMinqin RenMinqin RenJeroen A. Van KanHarry J. Whitlowsubject
Nuclear and High Energy PhysicsChemistrybusiness.industryFourier opticsScanning confocal electron microscopyTriplet lensIonOpticsQuadrupoleFigure of meritFocus (optics)businessInstrumentationBeam (structure)description
Abstract The central peak widths of the 2D-autocorrelation function have been investigated as a Figure of Merit (FoM) of focus quality in nuclear microscopy using a quadrupole triplet lens system. The beam focus could be reliably characterised for direct scanning transmission ion microscopy (direct-STIM) images obtained with fluences as small as 5.8 × 10 9 ions cm - 2 which colocalisation tests showed did not introduce significant beam-induced changes in the cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-06-01 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms |