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RESEARCH PRODUCT
Isolation, Identification, and Chemical Synthesis of 6α-Hydroxyraumacline: A Novel Alkaloid from CultivatedRauwolfia serpentinaCells
Hiromitsu TakayamaJoachim StöckigtNorio AimiShin-ichiro SakaiShinya SudaSusanne Endreßsubject
PharmacologyRauvolfiabiologyIndole alkaloidApocynaceaeAlkaloidChemical structureOrganic ChemistryPharmaceutical ScienceIsolation (microbiology)biology.organism_classificationChemical synthesisAnalytical ChemistryAjmalineComplementary and alternative medicineBiochemistryDrug DiscoverymedicineMolecular Medicinemedicine.drugdescription
From RAUWOLFIA SERPENTINA cells cultivated in the presence of ajmaline ( 2) the new indole alkaloid, 6alpha-hydroxyraumacline ( 1), was isolated. This alkaloid also occurs in significant amounts in the nutrition medium. A simple chemical synthesis of 1 was developed starting from ajmaline ( 2).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-10-01 | Planta Medica |