Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.

6533b85ffe1ef96bd12c2581

RESEARCH PRODUCT

Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.

Giuseppe Badalamenti Gaetano Leto Carla Flandina Chiara Ancona Lorena Incorvaia Fabio Fulfaro Marilena Crescimanno Maria Vittoria Sepporta

subject

0301 basic medicine Cancer Research Follistatin Cathepsin L Bone Neoplasms Breast Neoplasms Activin Cathepsin L 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Preliminary report medicine Biomarkers Tumor Humans bone metastasi Cystatin C Neoplasm Metastasis skin and connective tissue diseases Aged Neoplasm Staging biology business.industry Bone metastasis General Medicine Middle Aged medicine.disease Therapeutic monitoring Activins Activin a 030104 developmental biology Oncology Cystatin C ROC Curve tumor markers 030220 oncology & carcinogenesis Settore BIO/14 - Farmacologia biology.protein Cancer research Disease Progression biomarker Osteoporosis Female Neoplasm Grading business hormones hormone substitutes and hormone antagonists Follistatin

description

This study was directed to assess the clinical impact of the circulating cathepsin L, cystatin C, activin A, and follistatin in breast cancer patients. The serum concentrations of these molecules were determined by immunoenzymatic assays, and their association with some clinico-pathological parameters of breast cancer progression was evaluated. Our results identified cystatin C and activin A as predictive markers for the presence of breast cancer and bone metastasis, respectively. Therefore, these proteins may have a clinical role as circulating biomarkers in the diagnosis and therapeutic monitoring of breast cancer patients.

year	journal	country	edition	language
2016-10-22	Cancer investigation

10.1080/07357907.2016.1222416 https://pubmed.ncbi.nlm.nih.gov/27636861

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