6533b85ffe1ef96bd12c25d3
RESEARCH PRODUCT
In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles
Lutz NuhnLutz NuhnSebastian RosigkeitPatricia RenzDetlef SchuppanDetlef SchuppanAlexander BroseLeonard KapsFriedrich FoersterM. AslamRosario HeckRudolf ZentelYong Ook KimIngo Lieberwirthsubject
Liver CirrhosisMaterials scienceBiomedical EngineeringNanogelsPharmaceutical ScienceCell LinePolyethylene GlycolsBiomaterialsMiceIn vivoFibrosisCationsmedicineAnimalsPolyethyleneimineGene silencingTissue DistributionGene SilencingRNA Small InterferingGene knockdownGene Transfer TechniquesCationic polymerizationHydrogelsmedicine.diseaseMolecular biologyCell biologyCell cultureSelf-healing hydrogelsNanoparticlesNanogeldescription
Cationic nanohydrogel particles loaded with anti-Col1α1 siRNA suppress collagen synthesis and deposition in fibrotic mice: Systemically administered 40 nm sized nanogel particles accumulate in collagen-expressing cells in the liver. Their siRNA payload induces a sequence specific in vivo gene knockdown affording an efficient antifibrotic effect in mice with liver fibrosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-10-13 | Advanced Healthcare Materials |