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RESEARCH PRODUCT
Durch sterische effekte stabilisierte ß-ketocarbonsäuren
Volker KrauseWolfgang LauerHorst WengenrothHerbert Meiersubject
Steric effectschemistry.chemical_compoundChemistryDecarboxylationOrganic ChemistryDrug DiscoveryOrganic chemistryKeto–enol tautomerismAliphatic compoundBiochemistryMedicinal chemistryTautomerEnoldescription
Abstract Increasing steric hindrance in β-keto carboxylic acids leads to an increasing kinetic stability towards decarboxylation, till systems are reached which are completely stable at room temperature. Simultaneously the tautomeric equilibrium is changed in favour of the (Z)-enol, and finally in favour of the (E)-configurated enol.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | Tetrahedron Letters |