6533b861fe1ef96bd12c4429
RESEARCH PRODUCT
Automated Cancer Marker Characterization in Human Plasma Using SUrface PLASMON Resonance in Array combined with Mass Spectrometry (SUPRA-MS)
Marven El OstaThérèse LebloisGéraldine LucchiPatrick DucoroySophie BellonRabah ZeggariWilfrid BoireauFabien Remy-martinsubject
ProteomicsChemistry(all)Immuno-sensor[SDV.CAN]Life Sciences [q-bio]/CancerMass spectrometryProteomicsbiosensor01 natural sciencesMass Spectrometry[ SDV.CAN ] Life Sciences [q-bio]/Cancer03 medical and health scienceschipSUPRA-MSSurface plasmon resonance[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics030304 developmental biologyCancer marker0303 health sciencesChromatographyChemistryImmuno sensor010401 analytical chemistryGeneral MedicineBiomarkerSurface Plasmon Resonance0104 chemical sciences3. Good healthBiomarker (cell)Characterization (materials science)Human plasmaChemical Engineering(all)"Surface Plasmon Resonance[ SPI.NANO ] Engineering Sciences [physics]/Micro and nanotechnologies/MicroelectronicsBiosensorchip"description
International audience; The combination of Surface Plasmon Resonance technology with Mass Spectrometry becomes a key method for the characterization of targeted proteins in the fields of diagnosis and functional proteomics. We demonstrated in this work the ability of our SPRi-chip to capture targeted protein in biological fluids and in situ analyze by MS and MS/MS modes through automated procedure to go beyond classical immunoassays. Here, we established a proof of concept of SUPRA-MS for the detection, the identification and the characterization of a potential breast cancer marker.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-10-10 |