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RESEARCH PRODUCT

756 The Effectiveness of RDW-CV in Differentiating Microcytic Anemia

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Backround: Iron deficiency anemia (IDA) and thalassemia are the most common microcytic anemia in children. Sometimes, expensive or invasive investigations are necessary for their distinction. Red cell distribution - coefficient variation (RDW-CV) is a new generation marker more often used in differentiating IDA from thalassemia. A number of hematological indices are also useful (Mentzer, Shine&Lal, Green&King, Ricerca). Aim To demonstrate the effectiveness RDW - CV in differentiating microcytic anemia. Method Retrospective study conducted on a total of 215 patients with microcytic anemia. Criteria for study group selection: MCV and Hb below the minimum age reference (mild anemia, Hb between 9–11 g/dl and moderate anemia from 8.5–9 g/dl), without a history of other hematologic disorders or chronic diseases. Sideremia was determined to all patients to confirm the diagnosis of IDA (the least expensive investigation for distinction). The RDW - CV > 16% was considered pathological. Results 98 patients had low levels of sideremia, 134 patients had mild anemia and 81 - moderate anemia. RDW-CV was significantly correlated with sideremia, strongly for the group with mild anemia (p Conclusions RDW-CV is useful in differentiating IDA, especially in mild forms. Although Green&King index is the most sensitive, we support Ricerca index for simple calculation formula.