6533b862fe1ef96bd12c6e75
RESEARCH PRODUCT
Pharmacological studies of 1-(p-chlorophenyl)propanol and 2-(1-hydroxy-3-butenyl)phenol: Two new non-narcotic analgesics designed by molecular connectivity
R. Giner-ponsG.m. Antón-fosM. C. Recio-iglesiasR. Garcia-domenechF. J. García-marchJorge GalvezJ.v. De Julián-ortizsubject
PharmacologyStereochemistryPropanolsButanolsAnalgesicPharmaceutical ScienceBiological activity1-PropanolPharmacologyAnalgesics Non-NarcoticRatsNon narcoticPropanolchemistry.chemical_compoundMiceNociceptionchemistryPhenolsIn vivoOral administrationDrug DesignPhenolAnimalsFemaleRats Wistardescription
Abstract Molecular topology has been applied to the design of new analgesic drugs. Linear discriminant analysis and connectivity functions were used to design two potentially suitable drugs which were synthesized and tested for analgesic properties by the acetic acid-induced abdominal constriction test in mice and the tail-flick test in rats. In mice, the compound 1-(p-chlorophenyl)propanol showed higher analgesic activity, both intraperitoneally and orally, than acetylsalicylic acid. 2-(1-Hydroxy-3-butenyl)phenol exhibited a lesser protective effect (70% of that shown by acetylsalicylic acid). In rats, acetylsalicylic acid gave the greatest protection against pain when administered intraperitoneally, while 1-(p-chlorophenyl)propanol was the most active orally. The 2-(1-hydroxy-3-butenyl)phenol, both intraperitoneally and orally, snowed the least protective effect. These results demonstrated the peripheral analgesic properties of the selected compounds, thus confirming the validity of the molecular design method.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-01-01 |