Photoexcitation of the P4480 State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2

6533b86cfe1ef96bd12c897f

RESEARCH PRODUCT

Photoexcitation of the P4480 State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2

Tom Resler Víctor A. Lórenz-fonfría Ramona Schlesinger Franziska Pranga-sellnau Mattia Saita Joachim Heberle

subject

0301 basic medicine 010405 organic chemistry Chemistry Channelrhodopsin General Chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Photoexcitation 03 medical and health sciences 030104 developmental biology Colloid and Surface Chemistry Biophysics

description

Channelrhodopsins (ChRs) are light-gated cation channels. In spite of their wide use to activate neurons with light, the photocurrents of ChRs rapidly decay in intensity under both continuous illum...

year	journal	country	edition	language
2018-07-23	Journal of the American Chemical Society

https://doi.org/10.1021/jacs.8b03931

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