6533b86dfe1ef96bd12c9f9d

RESEARCH PRODUCT

Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits

Antti HuuskonenJani LappalainenMatti SanttilaKeijo HäkkinenHeikki KyröläinenNiku OksalaMustafa Atalay

subject

LeptinMaleAnatomy and PhysiologyLiikuntatiede - Sport and fitness sciencesMuscle FunctionsEpidemiologyRespiratory SystemPhysical fitnesslcsh:MedicineCardiovascular SystemBody Mass Indexlcsh:ScienceMusculoskeletal SystemMultidisciplinaryIGF1VO2 maxAdipose TissueGenetic EpidemiologyBody CompositionCirculatory PhysiologyReceptors LeptinMuscleMedicinePublic HealthWaist CircumferenceBehavioral and Social Aspects of HealthResearch ArticleAdultmedicine.medical_specialtyWaistAlpha-Ketoglutarate-Dependent Dioxygenase FTOBiologyPolymorphism Single NucleotideOxygen ConsumptionInternal medicineGeneticsmedicineHumansAerobic exerciseRespiratory PhysiologySports and Exercise MedicineMuscle SkeletalExerciseBiologyGenetic Association StudiesAerobic capacityLeptin receptorbusiness.industrylcsh:RProteinsnutritional and metabolic diseasesHuman Geneticsmedicine.diseaseObesityOikeuslääketiede ja muut lääketieteet - Forensic science and other medical sciencesEndocrinologylcsh:QPreventive MedicinebusinessBody mass index

description

Purpose Poor physical fitness and obesity are risk factors for all cause morbidity and mortality. We aimed to clarify whether common genetic variants of key energy intake determinants in leptin (LEP), leptin receptor (LEPR), and fat mass and obesity-associated (FTO) are associated with aerobic and neuromuscular performance, and whether aerobic fitness can alter the effect of these genotypes on body composition. Methods 846 healthy Finnish males of Caucasian origin were genotyped for FTO (rs8050136), LEP (rs7799039) and LEPR (rs8179183 and rs1137101) single nucleotide polymorphisms (SNPs), and studied for associations with maximal oxygen consumption, body fat percent, serum leptin levels, waist circumference and maximal force of leg extensor muscles. Results Genotype AA of the FTO SNP rs8050136 associated with higher BMI and greater waist circumference compared to the genotype CC. In general linear model, no significant interaction for FTO genotype-relative VO2max (mL·kg−1·min−1) or FTO genotype-absolute VO2max (L·min−1) on BMI or waist circumference was found. Main effects of aerobic performance on body composition traits were significant (p<0.001). Logistic regression modelling found no significant interaction between aerobic fitness and FTO genotype. LEP SNP rs7799039, LEPR SNPs rs8179183 and rs1137101 did not associate with any of the measured variables, and no significant interactions of LEP or LEPR genotype with aerobic fitness were observed. In addition, none of the studied SNPs associated with aerobic or neuromuscular performance. Conclusions Aerobic fitness may not modify the effect of FTO variation on body composition traits. However, relative aerobic capacity associates with lower BMI and waist circumference regardless of the FTO genotype. FTO, LEP and LEPR genotypes unlikely associate with physical performance. Public Library of Science open access

yearjournalcountryeditionlanguage
2012-07-29PLoS ONE
https://doi.org/10.1371/journal.pone.0051635