6533b86dfe1ef96bd12caa3a
RESEARCH PRODUCT
A New Tetrahydrofuran Derivative from the Endophytic Fungus Chaetomium sp. Isolated from Otanthus maritimus
Rainer EbelRuangelie Edrada-ebelAmal H. AlyWerner E. G. M�llerAbdessamad DebbabVictor WrayPeter ProkschWenhan Linsubject
Magnetic Resonance SpectroscopyStereochemistryChemical structureAntineoplastic AgentsFungusAsteraceaeChaetomiumMass SpectrometryGeneral Biochemistry Genetics and Molecular BiologyMicechemistry.chemical_compoundCell Line TumorBotanyAnimalsLeukemia L5178FuransPlants MedicinalbiologyStrain (chemistry)AsteraceaeChaetomiumbiology.organism_classificationOtanthuschemistryCell cultureGrowth inhibitionPolarographydescription
1 A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (), along with 5 known natural products, 2 - 6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 μg/mL, respectively, whereas 1 was inactive
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-08-15 | Zeitschrift für Naturforschung C |