6533b86efe1ef96bd12cb469
RESEARCH PRODUCT
Increased respiratory burst activity of monocytes and polymorphonuclear leukocytes in psoriasis.
E.-m. LemmelR. E. SchopfP. Altmeyersubject
AdultMaleNeutrophilsCytological TechniquesDermatologyMonocyteschemistry.chemical_compoundPsoriasismedicineHumansPsoriasisIn patientPatient groupAgedbusiness.industryZymosanZymosanMiddle Agedmedicine.diseaseControl subjectsPeripheral bloodIn vitroRespiratory burstOxygenchemistryImmunologyLuminescent MeasurementsFemalebusinessdescription
SUMMARY We studied the respiratory burst activity of peripheral blood monocytes and polymorphonu clear leukocytes (PMN) in eleven patients with psoriasis and eleven healthy controls, using zymosan particles to activate the phagocytes in vitro. The activation of the phagocytes was measured in a luminol-enhanced chemiluminescence (CL) assay. We found a significantly higher respiratory burst activity of both monocytes and PMN in patients with psoriasis compared with the control subjects. The percentages of monocytes in psoriatics did not differ from those of the controls. The higher amount of zymosan-induced CL activity generated in the patient group was unrelated to the age of the individual. Our data indicate increased metabolic reactivity of both monocytes and PMN in psoriasis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1982-11-01 | The British journal of dermatology |