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RESEARCH PRODUCT
Immunosurveillance by gamma delta T cells - lessons from the cancer field
M SerranoElisa BindaA RobertAdrian HaydayAdrian HaydayFrancesco Dielisubject
DeltaMedicine(all)Biochemistry Genetics and Molecular Biology(all)Innate lymphoid cellCancerInflammationGeneral MedicineBiologymedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologyImmunosurveillanceInvited Lecture PresentationImmune systemInnate responseMyeloid cellsImmunologymedicinemedicine.symptomdescription
The most common contemporary depiction of the immune response is an early innate response, mounted by myeloid cells, followed by a delayed adaptive lymphoid responses mounted by lymphocytes. This depiction is based on myriad compelling data sets and has made powerful predictions with biological and clinical relevance. Nonetheless, it seems incomplete. Thus, there are lymphocytes that respond very rapidly, commonly to self-encoded molecules over-expressed by dysregulated and/or transformed tissues and cells. The evidence for such “lymphoid stress-surveillance” by gamma delta T cells has been provided by animal models, and supports ongoing clinical investigations of the potential host-protective role of gamma delta T cells in cancer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-11-01 | Journal of Translational Medicine |