6533b870fe1ef96bd12cf24f
RESEARCH PRODUCT
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Jean-pierre HugotMauro D'amatoCarsten BüningCisca WijmengaMichel GeorgesTimothy H. FlorinChristopher G. MathewRichard B. GearryJoshua C. BisSeverine VermeireDeborah D. ProctorMark S. SilverbergRichard H. DuerrLaura StronatiHein W. VerspagetGraham L. Radford-smithWilliam G. NewmanJames LeeTalin HarituniansRenata D'incàMario CottoneMiguel RegueiroFrank SeiboldJerome I. RotterArie LevineSubra KugathasanPhilip SchummSoumya RaychaudhuriMarla DubinskyJack SatsangiCathryn EdwardsDenis FranchimontJürgen GlasJürgen GlasJürgen GlasAndré Van GossumEdouard LouisTodd GreenJulián PanésDavid C. WhitemanPaul RutgeertsMurray L. BarclayRichard K RussellMiquel SansGerd A. Kullak-ublickJean Frederick ColombelCarl A. AndersonAnne M. PhillipsNatalie J. PrescottA. Hillary SteinhartSuzanne BumpsteadAmir KarbanVito AnneseThomas D. WaltersHakon HakonarsonAnna LatianoDavid EllinghausPieter C. F. StokkersLeif TörkvistCraig MowatIan C. LawranceKent D. TaylorCécile LibioulleRinse K. WeersmaJohn D. RiouxGrant W. MontgomeryCharlie W. LeesMarc LémannTed DensonDavid C. WilsonStephan BrandJudy H. ChoSteven R. BrantRobert N. BaldassanoTheodore M. BaylessJeremy D. SandersonTariq AhmadLisa A. SimmsStephen L. GutheryMark J. DalyRebecca L. RobertsDebby LaukensJonas HalfvarsonLuke JostinsMiles ParkesJohn C. MansfieldAlbert CohenEleonora M. FestenYashoda SharmaAnne M. GriffithsAndre FrankeStephan R. TarganStefan SchreiberDermot P.b. McgovernJeffrey C. BarrettKai WangMartine De VosTobias Balschunsubject
Candidate geneGenetic LinkagePROTEINGenome-wide association studyInflammatory bowel diseaseGenomeACTIVATION0302 clinical medicineCrohn DiseaseSEQUENCE VARIANTSGenetics0303 health sciencesGenomeNEDD4 FAMILYCOMMON VARIANTSASSOCIATION3. Good health030220 oncology & carcinogenesis10076 Center for Integrative Human PhysiologyComputational Biology; Crohn Disease; Genetic Linkage; Genetic Loci; Genetic Variation; Genome Human; Humans; Reproducibility of Results; Genetic Predisposition to Disease; Genome-Wide Association Study; Geneticsinflammatory-bowel-disease sequence variants common variants nedd4 family association gene identification receptor protein activationHuman/dk/atira/pure/subjectarea/asjc/1300/1311Locus (genetics)610 Medicine & healthBiology03 medical and health sciences1311 GeneticsGenetic linkagemedicineGeneticsHumansGenetic Predisposition to Disease030304 developmental biologyGenetic associationIDENTIFICATIONRECEPTORComputational BiologyGenetic VariationReproducibility of Resultsmedicine.diseaseGENESettore MED/03 - Genetica Medica10199 Clinic for Clinical Pharmacology and ToxicologyGenetic Loci570 Life sciences; biologyHuman genomegenome-wide scan.meta-analysis.crohn's diseaseGenome-Wide Association StudyINFLAMMATORY-BOWEL-DISEASEdescription
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10(-8)). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-12-01 |