6533b870fe1ef96bd12d04f8

RESEARCH PRODUCT

Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts

James DeschnerPeer W. KämmererKerstin M. GallerBehrus PuladiLina GölzAndreas FriebeAgnes SchröderYüksel KorkmazTim SparwasserWilhelm Bloch

subject

Periodontium0301 basic medicinealveolar bonecementoclastslcsh:Chemistrychemistry.chemical_compound0302 clinical medicineCathepsin Kheterocyclic compoundsperiodontitisCyclic GMPlcsh:QH301-705.5SpectroscopyGeneral MedicineComputer Science ApplicationsResorptionCell biologymedicine.anatomical_structurecardiovascular systemOxidation-Reductioncementuminorganic chemicalsPeriodontal LigamentIronAntigens Differentiation MyelomonocyticHemeArticleCatalysisNitric oxideInorganic Chemistry03 medical and health sciencesstomatognathic systemAntigens CDnitric oxideOsteoclastmedicineAnimalsHumansddc:610CementumPhysical and Theoretical ChemistryMolecular BiologyCyclic guanosine monophosphateInflammationOrganic Chemistrysoluble guanylyl cyclase030206 dentistryPeriodontiumcGMPosteoclasts030104 developmental biologyGene Expression Regulationlcsh:Biology (General)lcsh:QD1-999chemistrySoluble guanylyl cyclase

description

Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. NO- and heme-independent activation of sGC requires protein expression of the &alpha

yearjournalcountryeditionlanguage
2021-01-07International Journal of Molecular Sciences
https://doi.org/10.3390/ijms22020539