6533b871fe1ef96bd12d0e47
RESEARCH PRODUCT
Ultrasmall particles for Gd-MRI and68Ga-PET dual imaging
Lucie SanceyFranck DenatPenelope BouziotisFrédéric BoschettiCharalambos TsoukalasFrançois LuxCharles TruilletConstantinos AnagnostopoulosMatteo MartiniVassilis KoutoulidisLia A. MoulopoulosJérémy BrugièreDimitris StellasThomas BrichartPascal PerriatI. BonnamourUlrich DarbostOlivier Tillementsubject
Multimodal imagingMaterials sciencemedicine.diagnostic_testGadoliniumNanoparticlechemistry.chemical_elementMagnetic resonance imaging02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesMr imagingDual imaging0104 chemical sciences3. Good healthNuclear magnetic resonancechemistryPositron emission tomographymedicineRadiology Nuclear Medicine and imagingGallium0210 nano-technologydescription
Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd(3+) ] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[(68) Ga(3+) ] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after (68) Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-05 | Contrast Media & Molecular Imaging |