Analysis of allergic immune responses in humanized mice.

6533b871fe1ef96bd12d0f88

RESEARCH PRODUCT

Analysis of allergic immune responses in humanized mice.

Iris Bellinghausen Joachim Saloga

subject

0301 basic medicine Male Allergy Biomedical Research Immunology Population Inflammation Mice SCID Immunoglobulin E T-Lymphocytes Regulatory 03 medical and health sciences Mice 0302 clinical medicine Immune system Hypersensitivity Medicine Animals Humans education Asthma education.field_of_study Transplantation Chimera biology business.industry Immunoglobulin E medicine.disease In vitro Asthma Disease Models Animal 030104 developmental biology Desensitization Immunologic Humanized mouse Immunology biology.protein Female medicine.symptom business 030215 immunology

description

Nowadays, more than 25% of the population in industrial countries are affected by IgE-mediated (atopic) allergic diseases such as allergic rhinitis, asthma and atopic eczema. Due to intensive research on basis of in vitro studies with human immune cells and different murine in vivo models of allergy fundamental mechanisms of allergic immune responses have been elucidated during the last years. However, human studies are restricted and the immune system of mice differs from the human immune system in several aspects so that the transferability of experimental results from mice to men is limited. Humanized mice represent a new tool to analyze the interaction of human immune cells under physiological conditions as far as possible, particularly to test novel therapeutic strategies. This review summarizes the impact of humanized mouse models for the investigation and treatment of allergic diseases.

year	journal	country	edition	language
2015-09-10	Cellular immunology

10.1016/j.cellimm.2016.07.008 https://pubmed.ncbi.nlm.nih.gov/27493097

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