6533b872fe1ef96bd12d3aac

RESEARCH PRODUCT

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Diego QuattroneUlrich ReininghausAlex L. RichardsGiada TripoliLaura FerraroAndrea QuattronePaolo MarinoVictoria RodriguezEdoardo SpinazzolaCharlotte Gayer-andersonHannah E. JongsmaPeter B. Jones La Cascia CaterinaDaniele La BarberaIlaria TarriconeElena BonoraSarah TosatoAntonio LasalviaAndrei SzökeCelso ArangoMiquel BernardoJulio BobesCristina Marta Del BenPaulo Rossi MenezesPierre-michel LlorcaJose Luis SantosJulio SanjuánManuel ArrojoAndrea TortelliEva VelthorstSteven BerendsenLieuwe De HaanBart P. F. RuttenMichael T. LynskeyTom P. FreemanJames B. KirkbridePak C. ShamMichael C. O'donovanAlastair G. CardnoEvangelos VassosJim Van OsCraig MorganRobin M. MurrayCathryn M. LewisMarta Di FortiKathryn HubbardStephanie BeardsSimona A. StiloMara ParelladaDavid FraguasMarta Rapado CastroÁLvaro Andreu-bernabeuGonzalo LópezMario MatteisEmiliano GonzálezManuel Durán-cutillaCovadonga M. Díaz-canejaPedro CuadradoJosé Juan Rodríguez SolanoAngel CarracedoJavier CostasEmilio SánchezSilvia AmorettiEsther Lorente-roviraPaz Garcia-portillaEstela Jiménez-lópezNathalie FrankeDaniella Van DamFabian TermorshuizenNathalie FrankeElsje Van Der VenElles MesschaartMarion LeboyerFranck Schu?rhoffStéphane JamainGrégoire BaudinAziz FerchiouBaptiste PignonJean-romain RichardThomas CharpeaudAnne-marie TroncheFlora FrijdaGiovanna MarrazzoLucia SideliCrocettarachele SartorioFabio SeminerioCamila Marcelino LoureiroRosana ShuhamaMirella RuggeriChiara BonettoDoriana CristofaloDomenico BerardiMarco SeriGiuseppe D?andrea

subject

medicine.medical_specialtyPsychosisPopulationNeurosciences. Biological psychiatry. NeuropsychiatryPHENOTYPESILLNESSPsychotic DisorderPredictive markersArticleCellular and Molecular NeuroscienceDEFICIT SYNDROMERisk FactorsFirst episode psychosismedicineSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.HumansCannabiClinical geneticsGenetic riskVALIDITYeducationSettore MED/25 - PsichiatriaSCHEDULEBiological PsychiatryMETAANALYSISCannabisUTILITYeducation.field_of_studyRisk FactorESQUIZOFRENIAASSOCIATIONCannabis usemedicine.diseaseBIFACTOR MODELPsychiatry and Mental healthPsychotic DisordersINTERRATER RELIABILITYSchizophreniaLinear ModelsSchizophreniaLinear ModelMedical geneticsPolygenic risk scorePsychologyHumanRC321-571Clinical psychology

description

The work was supported by Guarantors of Brain post-doctoral clinical fellowship to DQ; Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; Heisenberg professorship from the German Research Founda- tion (grant no. 389624707) to UR; the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). The Brazilian study was funded by the São Paulo Research Foundation under grant number 2012/0417-0.

10.1038/s41398-021-01526-0http://hdl.handle.net/10651/63453