6533b872fe1ef96bd12d3b1a
RESEARCH PRODUCT
Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
Arndt HartmannPeter RubenwolfJohannes BreyerMaximilian BurgerWolfgang Ottosubject
Invasion depthPathologymedicine.medical_specialtyUrologyCarcinoma in situShort CommunicationBladder030232 urology & nephrologycarcinoma in situMolecular evidenceBiologymedicine.disease03 medical and health sciences0302 clinical medicineOncologyAquaporin 3030220 oncology & carcinogenesisimmunohistochemistrymedicineImmunohistochemistryUrotheliumaquaporin 3Grading (tumors)urothelial carcinomaUrothelial carcinomadescription
We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific survival, this report investigates the expression of AQP3 in associated CIS. Contrary to what we had expected, all CIS specimens were shown to exhibit strong AQP3 expression, suggesting loss of AQP3 in UBC is primarily associated with the ability of tumor cells for invasion but not with grading as sign of dedifferentiation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-27 | Bladder Cancer (Amsterdam, Netherlands) |