6533b873fe1ef96bd12d4d9b

RESEARCH PRODUCT

Patterns of adjuvant chemotherapy for stage II and III colon cancer in France and Italy

Pamela MinicozziJean FaivreMilena SantVéronique BouvierPascale GrosclaudeAnne Marie Bouvier

subject

AdultMaleOncologymedicine.medical_specialtyAdolescentAdjuvant chemotherapyColorectal cancermedicine.medical_treatmentStage iiLower riskDisease-Free SurvivalInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansIn patientStage (cooking)ChildAgedNeoplasm StagingRetrospective StudiesAged 80 and overChemotherapyHepatologybusiness.industryInfant NewbornGastroenterologyInfantMiddle Agedmedicine.diseaseCancer registryItalyChemotherapy AdjuvantChild PreschoolColonic NeoplasmsPractice Guidelines as TopicFemaleFranceGuideline Adherencebusiness

description

European guidelines recommend adjuvant chemotherapy for stage III colon cancer but not for stage II.To determine the extent to which adjuvant chemotherapy was used in Italy and France.A common retrospective database of 2186 colon cancers diagnosed between 2003 and 2005 was analysed according to age, stage and presenting features.38.9% of patients with stage II and 64.6% with stage III received chemotherapy in Italy, 21.7% and 65.1% in France. For stage II, the association between country and chemotherapy was only significant in patients diagnosed out of emergency (ORItaly/France: 3.05 [2.12-4.37], p0.001) whereas patients diagnosed in emergency were as likely to receive chemotherapy in both countries. For stage III, there was a trend to a higher administration of chemotherapy for elderly patients in France compared to Italy. French patients were more likely than Italian to receive chemotherapy (OR: 1.91[1.32-2.78], p=0.001).Chemotherapy for stage III colon cancer was as extensively used in Italy as in France for young patients. Its administration could be increased in patients over 75. Stage II patients with a lower risk of relapse received chemotherapy more often in Italy than in France.

yearjournalcountryeditionlanguage
2013-08-01Digestive and Liver Disease
https://doi.org/10.1016/j.dld.2012.12.019