6533b873fe1ef96bd12d5875
RESEARCH PRODUCT
Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract
José-luis RíosMiguel Cerdá-nicolásMaría-carmen RecioMatthias Hamburgersubject
Anti-Inflammatory AgentsAdministration OralPharmaceutical ScienceArthritisPharmacognosyAnalytical Chemistrylaw.inventionArthritis RheumatoidMicelawDrug DiscoveryGastric mucosamedicineAnimalsEdemaIsatisPharmacologyDose-Response Relationship DrugbiologyTraditional medicinePlant Extractsbusiness.industryMacrophagesOrganic ChemistryIsatisbiology.organism_classificationmedicine.diseaseRatsIsatis tinctoriaRadiographyNitric oxide synthaseDose–response relationshipmedicine.anatomical_structureComplementary and alternative medicineRats Inbred Lewbiology.proteinMolecular MedicineFemalePhytotherapybusinessPhytotherapydescription
A dichloromethane extract of Isatis tinctoria was tested in the adjuvant-induced arthritis model in rats. The extract (150 mg/kg p. o.) leads to a significant reduction of paw oedema. Radiographic, histological and clinical assessment confirmed reduced damage of cartilage and signs of inflammatory response in comparison to untreated control. No significant differences were observed in the tissular levels of cyclooxygenases 1 and -2, and of inducible nitric oxide synthase in Isatis treated and untreated animals. High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-06-02 | Planta Medica |