6533b874fe1ef96bd12d63d0

RESEARCH PRODUCT

Flavonoids from Acacia pennata and their Cyclooxygenase (COX-1 and COX-2) Inhibitory Activities

Shigenobu AriharaAlain B. DongmoKazuko YoshikawaMarie Aleth Lacaille-duboisTomofumi Miyamoto

subject

FlavonoidIsovitexinPharmaceutical ScienceBiologyPharmacognosyAnalytical ChemistryInhibitory Concentration 50chemistry.chemical_compoundDrug DiscoveryHumansCyclooxygenase InhibitorsPhenolsIsorhamnetinPharmacologychemistry.chemical_classificationTraditional medicinePlant ExtractsOrganic ChemistryAcaciaFlavonesPlant LeavesComplementary and alternative medicinechemistryBiochemistryCyclooxygenase 2ApigeninCyclooxygenase 1Molecular MedicineKaempferolQuercetinPhytotherapy

description

Two new flavonoids quercetin 4'-O-alpha-L-rhamnopyranosyl-3-O-beta-D-allopyranoside (1) and apigenin 6-C-[2''-O-(E)-feruloyl- beta-D-glucopyranosyl]-8-C-beta-glucopyranoside (2), along with the known isorhamnetin 3-O-alpha-L-rhamnopyranoside (3), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside (4), and isovitexin (5) were isolated from the leaves of Acacia pennata Willd. (Mimosaceae) and tested for their anti-inflammatory activity. Their structures were determined by 1D and 2D NMR and mass spectrometry. They were tested for an inhibitory effect on COX-1 and COX-2, showing 60-90% inhibition at 10(-4) g/mL and 5-14% inhibition at 10(-4) g/mL, respectively.

yearjournalcountryeditionlanguage
2007-09-08Planta Medica
https://doi.org/10.1055/s-2007-981596